An investigational, once-daily oral GLP-1 medication being studied for the treatment of type 2 diabetes and obesity. Designed to help lower blood sugar and support weight loss in a convenient pill form, with clinical data emerging from the ACHIEVE and ATTAIN orforglipron Phase 3 programs.
Orforglipron is an investigational, once-daily oral GLP-1 receptor agonist being studied for type 2 diabetes and obesity. It belongs to a class of medicines called GLP-1 receptor agonists and is designed to help lower blood sugar and support weight loss. In clinical trials, including ACHIEVE-1 and ATTAIN-1, orforglipron was taken once a day at any time, without food or water restrictions. Learn more in our “What is orforglipron?” article.
Built on decades of pharmaceutical research and development expertise, ensuring the highest standards of quality and efficacy.
Designed with patient needs at the forefront, focusing on improving quality of life and treatment outcomes.
Rigorous safety protocols and comprehensive clinical trials ensure patient safety remains our top priority.
Supporting healthcare providers and patients worldwide with accessible, high-quality treatment options.
Backed by a dedicated team of researchers, clinicians, and healthcare professionals committed to excellence.
Ongoing research and development to advance treatment options and improve patient outcomes.
Orforglipron is available in various strengths to meet individual patient needs. Consult with your healthcare provider to determine the appropriate dosage.
Low strength formulation designed for initial treatment protocols and patient management.
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Medium strength option for patients requiring enhanced therapeutic response.
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Higher strength formulation for patients needing increased dosage levels.
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Maximum strength option for patients requiring the highest therapeutic dose.
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Our commitment to research and development drives innovation in healthcare. Through collaborative efforts with healthcare professionals and institutions worldwide, we continue to push the boundaries of medical science.
Orforglipron represents the culmination of years of dedicated research, clinical trials, and scientific discovery, all aimed at improving patient outcomes.
Learn About Our ResearchOur research is guided by scientific rigor, ethical standards, and a commitment to advancing medical knowledge for the benefit of patients worldwide.
Orforglipron has undergone extensive clinical development through rigorous Phase I, II, and III trials. Our research program involved thousands of patients across multiple countries, ensuring robust data collection and comprehensive safety profiling.
The clinical development process for Orforglipron followed international guidelines and regulatory standards, with studies designed to evaluate efficacy, safety, and optimal dosing regimens across diverse patient populations.
Our research team has dedicated years to understanding the molecular mechanisms and therapeutic potential of Orforglipron. Through advanced laboratory research and translational studies, we've gained deep insights into how this medication works at the cellular level.
The development of Orforglipron represents a significant advancement in pharmaceutical science, combining cutting-edge molecular design with clinical expertise to create a treatment option that addresses unmet medical needs.
Our research efforts are strengthened through partnerships with leading academic institutions, research organizations, and healthcare facilities worldwide. These collaborations enable us to conduct comprehensive studies and share knowledge that advances the entire field of medicine.
We work closely with regulatory authorities, patient advocacy groups, and healthcare professionals to ensure our research addresses real-world needs and contributes to improved patient outcomes globally.
Comprehensive clinical trials conducted with the highest standards of scientific rigor and ethical oversight.
Cutting-edge research in molecular biology, pharmacology, and clinical medicine to advance treatment options.
Working with leading medical institutions, researchers, and healthcare professionals worldwide.
Orforglipron is an investigational, once-daily oral GLP-1 medication being studied for the treatment of type 2 diabetes and obesity. It belongs to a class of medicines called GLP-1 receptor agonists and is designed to help lower blood sugar and support weight loss. It comes in a pill form. In clinical trials, it was taken once a day at any time, without food or water restrictions.
Orforglipron is currently being evaluated for safety in the treatment of weight loss and type 2 diabetes through clinical trials conducted by Lilly. Preliminary results have been positive, and additional data are expected to be released in the first quarter of 2026. It is not yet approved for use.
Lilly announced ATTAIN-1 topline trial results for orforglipron in obesity in August of 2025. ATTAIN-1 full results were presented at the European Association for the Study of Diabetes Annual Meeting and published in the New England Journal of Medicine in September 2025.
Lilly announced ATTAIN-2 topline for orforglipron in obesity with type 2 diabetes in August of 2025. ATTAIN-2 full results were presented at the ObesityWeek annual conference and published in The Lancet in November 2025.
Lilly announced ACHIEVE-1 topline clinical trial results for orforglipron in type 2 diabetes in April 2025. The full results were presented at the American Diabetes Association annual meeting and published in the New England Journal of Medicine in June 2025.
Lilly announced ACHIEVE-3 clinical trial results for orforglipron compared to oral semaglutide in people with type 2 diabetes in September 2025.
In October 2025, Lilly announced ACHIEVE-2 topline clinical trial results in which orforglipron was compared to dapagliflozin (an SGLT-2 inhibitor) in adults with type 2 diabetes inadequately controlled on metformin. At the same time, Lilly also announced ACHIEVE-5 topline clinical trial results in which orforglipron was evaluated versus placebo in adults with type 2 diabetes and inadequate glycemic control with insulin glargine.
Lilly announced ACHIEVE-3 clinical trial results for orforglipron compared to oral semaglutide in people with type 2 diabetes in September 2025.
In October 2025, Lilly announced ACHIEVE-2 topline clinical trial results in which orforglipron was compared to dapagliflozin (an SGLT-2 inhibitor) in adults with type 2 diabetes.
Lilly's orforglipron ACHIEVE clinical trial program is focused on adults with type 2 diabetes. The ATTAIN clinical trial program is focused on adults with obesity.
No. Lilly submitted orforglipron for regulatory review for the treatment of overweight or obesity in 2025, and plans to submit for type 2 diabetes in 2026.
Orforglipron was recently selected for the U.S. FDA Commissioner's National Priority Review Voucher pilot program.
Orforglipron was discovered by Chugai Pharmaceutical Co., Ltd. and licensed by Lilly in 2018. Lilly holds worldwide development and commercialization rights for orforglipron.
Lilly recently announced an agreement with the U.S. government to expand access to its obesity medicines and reduce patient costs. Upon FDA approval, self-pay patients living with obesity will be able to access orforglipron through LillyDirect's self-pay pharmacy channel with the lowest dose starting at $149 with additional doses up to $399.
Orforglipron is still in development, and not available to the public. It is still being studied in clinical trials. If approved, information about availability will be shared by Lilly and your healthcare provider.
In December 2025, Lilly announced the topline results of the ATTAIN-MAINTAIN trial, evaluating whether orforglipron helped adults maintain weight loss achieved with injectable obesity management medications.
Orforglipron has successfully completed six Phase 3 clinical trials:
Results from the final ongoing trial, ACHIEVE-4 (focused on type 2 diabetes) are expected to be announced in the first half of 2026.
Additional trials in the ATTAIN program are underway to investigate orforglipron in obstructive sleep apnea, hypertension and osteoarthritis pain of the knee in adults with obesity, as well as stress urinary incontinence and cardiovascular and renal outcomes.
Continue exploring investigational orforglipron with detailed articles on mechanism of action, weight loss results, side effects, clinical trials, FDA review timelines and pricing.
Read about orforglipron’s GLP‑1 mechanism of action, structure, and key Phase 3 clinical data.
Learn more about orforglipron GLP‑1Dive into ATTAIN-1, ATTAIN-2, ACHIEVE-1 and other orforglipron clinical trials for obesity and diabetes.
Orforglipron weight loss dataSee how orforglipron compares with tirzepatide, semaglutide, Zepbound and Rybelsus.
Orforglipron vs other GLP‑1 therapiesBrowse our orforglipron dosing strengths and place your order. We'll get back to you shortly.
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