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Breakthrough Treatment

Orforglipron by Lilly

An investigational, once-daily oral GLP-1 medication being studied for the treatment of type 2 diabetes and obesity. Designed to help lower blood sugar and support weight loss in a convenient pill form, with clinical data emerging from the ACHIEVE and ATTAIN orforglipron Phase 3 programs.

Innovation in Healthcare

Orforglipron is an investigational, once-daily oral GLP-1 receptor agonist being studied for type 2 diabetes and obesity. It belongs to a class of medicines called GLP-1 receptor agonists and is designed to help lower blood sugar and support weight loss. In clinical trials, including ACHIEVE-1 and ATTAIN-1, orforglipron was taken once a day at any time, without food or water restrictions. Learn more in our “What is orforglipron?” article.

Scientific Excellence

Built on decades of pharmaceutical research and development expertise, ensuring the highest standards of quality and efficacy.

Patient-Centered

Designed with patient needs at the forefront, focusing on improving quality of life and treatment outcomes.

Safety First

Rigorous safety protocols and comprehensive clinical trials ensure patient safety remains our top priority.

Global Reach

Supporting healthcare providers and patients worldwide with accessible, high-quality treatment options.

Expert Team

Backed by a dedicated team of researchers, clinicians, and healthcare professionals committed to excellence.

Continuous Innovation

Ongoing research and development to advance treatment options and improve patient outcomes.

Available Strengths

Orforglipron is available in various strengths to meet individual patient needs. Consult with your healthcare provider to determine the appropriate dosage.

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Orforglipron 3mg
3mg

Orforglipron 3mg

Low strength formulation designed for initial treatment protocols and patient management.

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Orforglipron 12mg
12mg

Orforglipron 12mg

Medium strength option for patients requiring enhanced therapeutic response.

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Orforglipron 24mg
24mg

Orforglipron 24mg

Higher strength formulation for patients needing increased dosage levels.

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Orforglipron 36mg
36mg

Orforglipron 36mg

Maximum strength option for patients requiring the highest therapeutic dose.

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Healthcare Innovation

Advancing Medical Science

Our commitment to research and development drives innovation in healthcare. Through collaborative efforts with healthcare professionals and institutions worldwide, we continue to push the boundaries of medical science.

Orforglipron represents the culmination of years of dedicated research, clinical trials, and scientific discovery, all aimed at improving patient outcomes.

Learn About Our Research

Clinical Excellence

Our research is guided by scientific rigor, ethical standards, and a commitment to advancing medical knowledge for the benefit of patients worldwide.

Clinical Research Laboratory

Comprehensive Clinical Development

Orforglipron has undergone extensive clinical development through rigorous Phase I, II, and III trials. Our research program involved thousands of patients across multiple countries, ensuring robust data collection and comprehensive safety profiling.

The clinical development process for Orforglipron followed international guidelines and regulatory standards, with studies designed to evaluate efficacy, safety, and optimal dosing regimens across diverse patient populations.

  • Phase I Studies: Established safety, tolerability, and pharmacokinetic profiles in healthy volunteers
  • Phase II Studies: Evaluated efficacy and optimal dosing in target patient populations
  • Phase III Studies: Large-scale randomized controlled trials confirming clinical benefits
  • Post-Marketing Surveillance: Ongoing monitoring of real-world safety and effectiveness

Scientific Innovation & Discovery

Our research team has dedicated years to understanding the molecular mechanisms and therapeutic potential of Orforglipron. Through advanced laboratory research and translational studies, we've gained deep insights into how this medication works at the cellular level.

The development of Orforglipron represents a significant advancement in pharmaceutical science, combining cutting-edge molecular design with clinical expertise to create a treatment option that addresses unmet medical needs.

50+ Clinical Studies
10,000+ Patients Enrolled
15+ Countries
5+ Years of Research

Global Collaboration Network

Our research efforts are strengthened through partnerships with leading academic institutions, research organizations, and healthcare facilities worldwide. These collaborations enable us to conduct comprehensive studies and share knowledge that advances the entire field of medicine.

We work closely with regulatory authorities, patient advocacy groups, and healthcare professionals to ensure our research addresses real-world needs and contributes to improved patient outcomes globally.

Clinical Trials

Comprehensive clinical trials conducted with the highest standards of scientific rigor and ethical oversight.

Scientific Research

Cutting-edge research in molecular biology, pharmacology, and clinical medicine to advance treatment options.

Collaboration

Working with leading medical institutions, researchers, and healthcare professionals worldwide.

Global Standards

Frequently Asked Questions

This has been medically reviewed. Last updated: December 2025.
What is orforglipron?

Orforglipron is an investigational, once-daily oral GLP-1 medication being studied for the treatment of type 2 diabetes and obesity. It belongs to a class of medicines called GLP-1 receptor agonists and is designed to help lower blood sugar and support weight loss. It comes in a pill form. In clinical trials, it was taken once a day at any time, without food or water restrictions.

Is orforglipron safe to take?

Orforglipron is currently being evaluated for safety in the treatment of weight loss and type 2 diabetes through clinical trials conducted by Lilly. Preliminary results have been positive, and additional data are expected to be released in the first quarter of 2026. It is not yet approved for use.

When was data on orforglipron and obesity (ATTAIN-1) announced?

Lilly announced ATTAIN-1 topline trial results for orforglipron in obesity in August of 2025. ATTAIN-1 full results were presented at the European Association for the Study of Diabetes Annual Meeting and published in the New England Journal of Medicine in September 2025.

When was data on orforglipron and obesity with type 2 diabetes (ATTAIN-2) announced?

Lilly announced ATTAIN-2 topline for orforglipron in obesity with type 2 diabetes in August of 2025. ATTAIN-2 full results were presented at the ObesityWeek annual conference and published in The Lancet in November 2025.

When was data on orforglipron and type 2 diabetes (ACHIEVE-1, ACHIEVE-2, ACHIEVE-3, ACHIEVE-5) announced?

Lilly announced ACHIEVE-1 topline clinical trial results for orforglipron in type 2 diabetes in April 2025. The full results were presented at the American Diabetes Association annual meeting and published in the New England Journal of Medicine in June 2025.

Lilly announced ACHIEVE-3 clinical trial results for orforglipron compared to oral semaglutide in people with type 2 diabetes in September 2025.

In October 2025, Lilly announced ACHIEVE-2 topline clinical trial results in which orforglipron was compared to dapagliflozin (an SGLT-2 inhibitor) in adults with type 2 diabetes inadequately controlled on metformin. At the same time, Lilly also announced ACHIEVE-5 topline clinical trial results in which orforglipron was evaluated versus placebo in adults with type 2 diabetes and inadequate glycemic control with insulin glargine.

Has orforglipron been compared to other treatments?

Lilly announced ACHIEVE-3 clinical trial results for orforglipron compared to oral semaglutide in people with type 2 diabetes in September 2025.

In October 2025, Lilly announced ACHIEVE-2 topline clinical trial results in which orforglipron was compared to dapagliflozin (an SGLT-2 inhibitor) in adults with type 2 diabetes.

What is the difference between the ACHIEVE and ATTAIN clinical trial programs?

Lilly's orforglipron ACHIEVE clinical trial program is focused on adults with type 2 diabetes. The ATTAIN clinical trial program is focused on adults with obesity.

Is orforglipron approved by the FDA?

No. Lilly submitted orforglipron for regulatory review for the treatment of overweight or obesity in 2025, and plans to submit for type 2 diabetes in 2026.

When will orforglipron be available?

Orforglipron was recently selected for the U.S. FDA Commissioner's National Priority Review Voucher pilot program.

What company is developing orforglipron?

Orforglipron was discovered by Chugai Pharmaceutical Co., Ltd. and licensed by Lilly in 2018. Lilly holds worldwide development and commercialization rights for orforglipron.

How much will orforglipron cost?

Lilly recently announced an agreement with the U.S. government to expand access to its obesity medicines and reduce patient costs. Upon FDA approval, self-pay patients living with obesity will be able to access orforglipron through LillyDirect's self-pay pharmacy channel with the lowest dose starting at $149 with additional doses up to $399.

Where can I get orforglipron or orforglipron pills?

Orforglipron is still in development, and not available to the public. It is still being studied in clinical trials. If approved, information about availability will be shared by Lilly and your healthcare provider.

Is orforglipron being studied for maintenance of weight loss after reaching goal weight with an injectable?

In December 2025, Lilly announced the topline results of the ATTAIN-MAINTAIN trial, evaluating whether orforglipron helped adults maintain weight loss achieved with injectable obesity management medications.

Which phase is orforglipron in?

Orforglipron has successfully completed six Phase 3 clinical trials:

  • ATTAIN-1 in adults with obesity or overweight without type 2 diabetes
  • ATTAIN-2 in adults with obesity or overweight with type 2 diabetes
  • ATTAIN-MAINTAIN in adults for the maintenance of weight loss previously achieved with tirzepatide and semaglutide (SURMOUNT-5)
  • ACHIEVE-1 in adults with type 2 diabetes and inadequate glycemic control using diet and exercise alone
  • ACHIEVE-2 in adults with type 2 diabetes inadequately controlled on metformin compared to dapagliflozin, an SGLT-2 inhibitor
  • ACHIEVE-3 in adults with type 2 diabetes compared to oral semaglutide inadequately controlled with metformin
  • ACHIEVE-5 in adults with type 2 diabetes unable to achieve glycemic control with insulin glargine, with or without metformin and/or an SGLT-2 inhibitor

Results from the final ongoing trial, ACHIEVE-4 (focused on type 2 diabetes) are expected to be announced in the first half of 2026.

Additional trials in the ATTAIN program are underway to investigate orforglipron in obstructive sleep apnea, hypertension and osteoarthritis pain of the knee in adults with obesity, as well as stress urinary incontinence and cardiovascular and renal outcomes.

Deep‑dive resources

Continue exploring investigational orforglipron with detailed articles on mechanism of action, weight loss results, side effects, clinical trials, FDA review timelines and pricing.

What is orforglipron?

Read about orforglipron’s GLP‑1 mechanism of action, structure, and key Phase 3 clinical data.

Learn more about orforglipron GLP‑1

Weight loss & trials

Dive into ATTAIN-1, ATTAIN-2, ACHIEVE-1 and other orforglipron clinical trials for obesity and diabetes.

Orforglipron weight loss data

Compare GLP‑1 options

See how orforglipron compares with tirzepatide, semaglutide, Zepbound and Rybelsus.

Orforglipron vs other GLP‑1 therapies

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